Investigating the mechanism of Echovirus 30 cell invasion

Yucai Liang; Junbing Chen; Congcong Wang; Bowen Yu; Yong Zhang; Zhijun Liu

doi:10.3389/fmicb.2023.1174410

Investigating the mechanism of Echovirus 30 cell invasion

Front Microbiol. 2023 Jul 6:14:1174410. doi: 10.3389/fmicb.2023.1174410. eCollection 2023.

Authors

Yucai Liang¹, Junbing Chen², Congcong Wang¹, Bowen Yu³, Yong Zhang⁴, Zhijun Liu¹

Affiliations

¹ Department of Microbiology, Weifang Medical University, Weifang, China.
² Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China.
³ Department of Immunology, Weifang Medical University, Weifang, China.
⁴ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Abstract

Viruses invade susceptible cells through a complex mechanism before injecting their genetic material into them. This causes direct damage to the host cell, as well as resulting in disease in the corresponding system. Echovirus type 30 (E30) is a member of the Enterovirus B group and has recently been reported to cause central nervous system (CNS) disorders, leading to viral encephalitis and viral meningitis in children. In this review, we aim to help in improving the understanding of the mechanisms of CNS diseases caused by E30 for the subsequent development of relevant drugs and vaccines.

Keywords: E30; aseptic meningitis; central nervous system; enterovirus; invasive mechanisms.

Publication types

Review