The 2022 monkeypox outbreak has created a new global health threat and pandemic. Monkeypox virus is a descendant of the genus Orthopoxvirus, producing a febrile skin rash disease in humans. Monkeypox is zoonotic transmitted and transmitted from human to human in several ways. Even though this disease is self-limited, it creates important community health worries due to its inconvenience and widespread complications. Herein, we discussed the up-to-date current situation of monkeypox regarding its epidemiology, clinical manifestations, current in-use therapeutics, necessary protective measures, and response to potential occurrences considering the recent pandemic. Also, in this review, a comparative genomic analysis of the recent circulating strains that have been recovered from various countries including, Egypt, USA, Spain, Japan and South Africa has been investigated.
Keywords: anti-virals; epidemiology; monkeypox virus; mutation; orthopoxviruses; transmission.
The recent monkeypox outbreaks in 2022 have created a new global health threat because of their high number of cases and the speed of infection. Infection of monkeypox is characterized by a febrile rash disease in humans and characteristic skin lesions. Monkeypox is transmitted to humans via various routes including, direct contact with infected humans or animals, or vial droplet means. Although, the disease is self-limited; however, it can cause important public health consequences, particularly in pediatric, immunocompromised individuals and during pregnancy. This review introduces the monkeypox illness epidemiology, clinical manifestations, genomic mutation of the circulating viral strains, and management.
© 2023 Khaled Aboshanab.