Biosafety evaluation of BaSi2O2N2:Eu2+/PDMS composite elastomers

Zheyuan Zhang; Mingrui Zong; Jinrong Liu; Jianing Ren; Xiaoming Liu; Ran Zhang; Jiayu Cui; Lingxiang Sun; Hao Song; Yanjie Zhang; Bing Li; Xiuping Wu

doi:10.3389/fbioe.2023.1226065

Biosafety evaluation of BaSi₂O₂N₂:Eu²⁺/PDMS composite elastomers

Front Bioeng Biotechnol. 2023 Jul 7:11:1226065. doi: 10.3389/fbioe.2023.1226065. eCollection 2023.

Authors

Zheyuan Zhang^{1

2}, Mingrui Zong^{1

2}, Jinrong Liu^{1

2}, Jianing Ren^{1

2}, Xiaoming Liu^{1

2}, Ran Zhang^{1

2}, Jiayu Cui^{1

2}, Lingxiang Sun^{1

2}, Hao Song³, Yanjie Zhang³, Bing Li^{1

2}, Xiuping Wu^{1

2}

Affiliations

¹ School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, Shanxi, China.
² Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, Shanxi, China.
³ Research Institute of Photonics, Dalian Polytechnic University, Dalian, Liaoning, China.

Abstract

In recent years, mechanoluminescent (ML) materials have shown great potential in stress sensing, mechanical energy collection and conversion, so they have attracted wide attention in the field of stomatology. In the early stage of this study, BaSi₂O₂N₂:Eu²⁺ ML phosphors were synthesized by two-step high temperature solid state method, and then mixed with Polydimethylsiloxane (PDMS) in different proportions to obtain BaSi₂O₂N₂:Eu²⁺/PDMS ML composites with different mass fractions (10%,20%,30%,40%,50%). Then its biosafety was evaluated by Cell Counting Kit-8 (CCK-8), Calcein-AM/PI fluorescence staining, hemolysis, oral mucosal irritation, acute and subacute systemic toxicity tests. The experimental results show that the biosafety of BaSi₂O₂N₂:Eu²⁺/PDMS ML composite elastomers with different mass fraction is in line with the existing standards, and other related properties can be further studied.

Keywords: BaSi2O2N2:Eu2+; biosafety; composite; mechanoluminescent; polydimethylsiloxane.

Grants and funding

This work was supported by Shanxi Province Science and Technology Innovation Key Talent Team (202204051002034), Central guide local science and technology development funds (transfer of scientific and technological achievements) project (YDZJSX 2021C011), Shanxi Province Key R&D Program (202102130501002) and Key country-specific science and technology cooperation projects of Shanxi Provincial Science and Technology Department (202204041101004).