Relationship between nocturia and hypertension: findings from the NHANES 2005-2016

Junhao Chen; Zhenghuan Liu; Luchen Yang; Jing Zhou; Kai Ma; Zhufeng Peng; Qiang Dong

doi:10.3389/fcvm.2023.1165092

Relationship between nocturia and hypertension: findings from the NHANES 2005-2016

Front Cardiovasc Med. 2023 Jul 6:10:1165092. doi: 10.3389/fcvm.2023.1165092. eCollection 2023.

Authors

Junhao Chen^#^{1

2}, Zhenghuan Liu^#^{1

2}, Luchen Yang^{1

2}, Jing Zhou^{1

2}, Kai Ma^{1

2}, Zhufeng Peng¹, Qiang Dong¹

Affiliations

¹ Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
² West China School of Medicine, Sichuan University, Chengdu, China.

^# Contributed equally.

Abstract

Objectives: The objective of this study was to explore the association between nocturia and hypertension in a large, nationally representative adult sample.

Methods: We used data from 2005 to 2016 National Health and Nutritional Examination Surveys (NHANES). A total of 29,505 participants aged 20 years old or older were included. A participant was considered to have nocturia if he or she had two or more voiding episodes at night. Multivariable logistic regression models were used to explore the association between nocturia and hypertension.

Results: Participants with nocturia were associated with a higher risk of hypertension (OR, 1.36; 95% CI, 1.28-1.45). Interaction tests revealed no significant effect of sex, age, race, or body mass index on the association of nocturia with hypertension. As the severity of nocturia increases, the risk of hypertension increases (P for trend <0.0001). In addition, nocturia was also related to different grades of hypertension (II vs. I: OR, 1.34, 95% CI, 1.16-1.55; III vs. I: OR, 1.67, 95% CI, 1.32-2.13).

Conclusion: In this cross-sectional study, our results suggest that nocturia is associated with an increased risk for hypertension.

Keywords: NHANES; clinical study; epidemiology; hypertension; nocturia.

Grants and funding

This work was supported by the National Key Research and Development Program of China (grant no: 2021YFC2009304), the Project of Science and Technology Department of Chengdu (grant no: 2021-YF05-00717-SN) and the Project of Science and Technology Department of Sichuan Province (grant no: 2021YFS0117). Sichuan Provincial Central Guidance Local Science and Technology Development Project: Molecular pathological mechanism of phthalate ester compounds inducing prostatic hyperplasia (grant no: 2022ZYD0058).