Enriched environment-induced neuroplasticity in ischemic stroke and its underlying mechanisms

Ping-Ping Han; Yu Han; Xin-Ya Shen; Zhen-Kun Gao; Xia Bi

doi:10.3389/fncel.2023.1210361

Enriched environment-induced neuroplasticity in ischemic stroke and its underlying mechanisms

Front Cell Neurosci. 2023 Jul 7:17:1210361. doi: 10.3389/fncel.2023.1210361. eCollection 2023.

Authors

Ping-Ping Han¹, Yu Han², Xin-Ya Shen³, Zhen-Kun Gao³, Xia Bi¹

Affiliations

¹ Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
² Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
³ Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Stroke is a common cerebrovascular disease that can interrupt local blood flow in the brain, causing neuronal damage or even death, resulting in varying degrees of neurological dysfunction. Neuroplasticity is an important neurological function that helps neurons reorganize and regain function after injury. After cerebral ischemia, neuroplasticity changes are critical factors for restoring brain function. An enriched environment promotes increased neuroplasticity, thereby aiding stroke recovery. In this review, we discuss the positive effects of the enriched environment on neuroplasticity after cerebral ischemia, including synaptic plasticity, neurogenesis, and angiogenesis. In addition, we also introduce some studies on the clinical application of enriched environments in the rehabilitation of post-stroke patients, hoping that they can provide some inspiration for doctors and therapists looking for new approaches to stroke rehabilitation.

Keywords: angiogenesis; enriched environment; ischemic stroke; neurogenesis; neuroplasticity.

Publication types

Review

Grants and funding

This study was supported by grants from the Key Discipline Project of Shanghai Pudong New Area, No. PWZxk2022-10 (to XB) and the Featured Clinical Discipline Project of Shanghai Pudong New Area, No. PWYts2021-10 (to XB).