Prevalence of hepatitis B and associated factors in the Buea Regional Hospital, Cameroon

Claudia Noumbissie Nzechieu Evenge; Elisabeth Zeuko'o Menkem; Eleonore Ngounou; Djakissam Watching; Erastus Nembo Nembu; Woquan Sama Luma; Armel Jackson Seukep; Francis Desire Bomba Taksinkou; Fabrice Fekam Boyom

doi:10.1016/j.heliyon.2023.e17745

Prevalence of hepatitis B and associated factors in the Buea Regional Hospital, Cameroon

Heliyon. 2023 Jul 4;9(7):e17745. doi: 10.1016/j.heliyon.2023.e17745. eCollection 2023 Jul.

Authors

Claudia Noumbissie Nzechieu Evenge¹, Elisabeth Zeuko'o Menkem^{1

2}, Eleonore Ngounou¹, Djakissam Watching³, Erastus Nembo Nembu¹, Woquan Sama Luma¹, Armel Jackson Seukep¹, Francis Desire Bomba Taksinkou¹, Fabrice Fekam Boyom²

Affiliations

¹ Department of Biomedical Sciences, University of Buea, Cameroon.
² Antimicrobial and Biocontrol Agent Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaoundé 1, Cameroon.
³ Department of Medical Laboratory Sciences, University of Buea, Cameroon.

Abstract

Introduction: Hepatitis B infection is a serious global health problem worldwide. In Cameroon, this infection shows a great variability in prevalence in the country and even within different population groups. However, the prevalence of HBV in the southwestern region is not yet known.

Objectives: This study was conducted to determine the prevalence of hepatitis B, its associated factors, and the patient's knowledge about the infection at the Buea Regional Hospital.

Method: We conducted a hospital-based cross-sectional study from March 29th to June 30th, 2021 involving participants of both sexes with ages ranging from 13 to 60+. A random sampling method was used to obtain a sample size of 113 participants as calculated using Lorentz's formula. The study questionnaires were administered to participants and their blood samples were collected by venous puncture. The blood samples were collected in non-hepainized test tube at the collection units of the Hospital. Diaspot one-step Hepatitis B Surface Antigen test strips with 99% sensitivity and 97% specificity were used to determine the status of the participants. The data were analysed using SPSS 25.0. Bivariate and multivariable analyses were used to obtain associated factors. The level of significance was set at p ≤ 0.05.

Results: A total of 125 participants were recruited. However, only 119 provided complete data (questionnaire and blood samples). A proportion 61 (51.3%) of the participants were females in the 20-29-year age group. The prevalence of hepatitis was 8.4%. Fifty-three percent (64) of the participants had adequate knowledge of Hepatitis B. Having had more than one sexual partner in the last six months and having visited a dentist in the past was significantly associated with Hepatitis B positive status (p ≤ 0.05).

Conclusion: The prevalence of Hepatitis B in the Buea Regional Hospital is 8.4% and 53.8% of the participants had adequate knowledge of the infection. Males were found to be 13.17 times more likely to be positive for Hepatitis B infection than females.

Keywords: Associated factors; Cameroon; Hepatitis B; Knowledge; Prevalence.