The aim of this study is to analyze the research hotspots and development trends in the field of pathogenesis of diabetic nephropathy in China from 2013 to 2022. Based on China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database, China Biology Medicine disc, Web of Science core collection and PubMed database, the related literatures in the field of pathogenesis of diabetic nephropathy in China from 2013 to 2022, were retrieved to establish the database, and the VOSviewer software was used for bibliometric analysis. A total of 1 664 Chinese and 2 149 English literatures are included in this study. The scientific research results from 2013 to 2022 have shown an overall increasing trend. The research hotspots in the field of pathogenesis of diabetic nephropathy in China are mainly concentrated in Podocytes, Oxidative stress, Inflammation, Renal fibrosis, Urine protein, etc. The frontier hotspots in this field include Biomarkers, Nrf2, Gut microbiota, NLRP3 inflammasome, Apoptosis, MicroRNA, etc. Through visual analysis, the research hotspots and frontier trends of the pathogenesis of diabetic nephropathy in China can be visually presented, and then provide new ideas and directions for the further in-depth research on the pathogenesis of diabetic nephropathy.
分析2013—2022年间我国糖尿病肾病发病机制的研究热点及发展趋势。本研究利用文献计量学方法，基于中国学术期刊全文数据库、万方数据知识服务平台、中文科技期刊数据库、中国生物医学文献数据库、科学网核心合集数据库和美国国家医学图书馆生物医学信息检索系统，借助VOSviewer软件对2013—2022年间中国研究人员发表的有关糖尿病肾病发病机制领域的文献进行可视化分析。研究共纳入中文文献1 664篇，英文文献2 149篇，结果显示：2013—2022年间，国内糖尿病肾病发病机制研究成果总体呈逐年增长趋势。共现分析显示：国内糖尿病肾病发病机制领域研究热点集中于足细胞、氧化应激、炎症、肾纤维化、尿蛋白等领域，前沿热点有生物标志物、Nrf2、肠道菌群、NLRP3炎症小体、细胞凋亡、微小RNA等。通过可视化分析可以直观呈现国内糖尿病肾病发病机制的研究热点及前沿趋势，进而为糖尿病肾病发病机制的后续研究提供新的思路和方向。.