Annexin A2: the missing piece in the puzzle of pathogen-induced damage

Chao Li; Jianwei Yu; Daoyong Liao; Xiaoling Su; Xinchao Yi; Xue Yang; Jun He

doi:10.1080/21505594.2023.2237222

Annexin A2: the missing piece in the puzzle of pathogen-induced damage

Virulence. 2023 Dec;14(1):2237222. doi: 10.1080/21505594.2023.2237222.

Authors

Chao Li¹, Jianwei Yu², Daoyong Liao¹, Xiaoling Su¹, Xinchao Yi¹, Xue Yang², Jun He¹

Affiliations

¹ The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, China.
² Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Abstract

Annexin A2 is a Ca²⁺ regulated protein belonging to the Annexin family and is found in the cytoplasm and cell membrane. It can exist in a monomeric form or in a heterotetrameric form with the S100A10 dimer. The research on Annexin A2 in tumours is currently active, and studies on its role in pathogen infection are increasing. Annexin A2 plays a crucial role in the life cycle of viruses by mediating adhesion, internalization, uncoating, transport, and release. In the case of parasites, bacteria, mycoplasma, fungi, and other pathogens, Annexin A2 binds to the ligand on the pathogen, which mediates the pathogen's adhesion to the host cell, ultimately leading to infection and damage to the host. Furthermore, some studies have developed biological or chemical drugs that target Annexin A2, which have demonstrated promising anti-infective effects. Thus, targeting Annexin A2 may present a promising therapeutic approach for the treatment of diverse infectious diseases. In summary, this paper provides an overview of Annexin A2 and its role in various pathogens. It highlights its regulation of pathogen infection and its potential as a therapeutic target for the treatment of infectious diseases.

Keywords: A2t; Annexin A2; S100A10; ligand; pathogen; therapeutic target.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Annexin A2* / metabolism
Cell Membrane / metabolism
Communicable Diseases*
Humans
S100 Proteins / metabolism

Substances

S100 Proteins
Annexin A2

Grants and funding

This work was supported by the Scientific Research Project of Hunan Provincial Health Committee under Grant No. 20201915; the Emergency special project of epidemic prevention and control of COVID-19 pneumonia in the University of South China under Grant No. 12; the Hengyang Science and Technology Planning Project under Grant No. 202250045307; and the Natural Science Foundation of Hunan Province under Grant No. 2022JJ40406.