Typhoid fever due to laboratory-acquired Salmonella Typhi, confirmed by core genome multi-locus sequence typing

Jorrit Broertjes; Rogier Jansen; Iedan Verly; Kim van der Zwaluw; Alje van Dam

doi:10.1016/j.diagmicrobio.2023.116016

Typhoid fever due to laboratory-acquired Salmonella Typhi, confirmed by core genome multi-locus sequence typing

Diagn Microbiol Infect Dis. 2023 Oct;107(2):116016. doi: 10.1016/j.diagmicrobio.2023.116016. Epub 2023 Jul 2.

Authors

Jorrit Broertjes¹, Rogier Jansen², Iedan Verly³, Kim van der Zwaluw⁴, Alje van Dam⁵

Affiliations

¹ Department of Medical Microbiology and Infection Prevention, University Medical Centers, Amsterdam, Netherlands. Electronic address: j.broertjes@amsterdamumc.nl.
² Department of Medical Microbiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands.
³ Department of Medical Microbiology and Infection Prevention, University Medical Centers, Amsterdam, Netherlands.
⁴ Centre for Infectious Disease Control, Diagnostics and Laboratory Surveillance (IDS), National Institute for Public Health and Environment, Bilthoven, Netherlands.
⁵ Department of Medical Microbiology and Infection Prevention, University Medical Centers, Amsterdam, Netherlands; Department of Medical Microbiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands.

PMID: 37481800
DOI: 10.1016/j.diagmicrobio.2023.116016

Abstract

We present a case of laboratory-acquired Salmonella Typhi, resulting in hospitalization of a technician. Blood and stool cultures revealed a S. Typhi strain, identical to the strain with which the employee had recently worked, confirmed using core-genome multilocus sequence typing. The incident occurred despite working in a biosafety cabinet.

Keywords: Biosafety; Laboratory-acquired infections; Multi-locus sequence typing; Salmonella Typhi.

Publication types

Case Reports

MeSH terms

Humans
Laboratories
Multilocus Sequence Typing / methods
Salmonella typhi* / genetics
Typhoid Fever* / diagnosis