Advances in Clinical Mass Cytometry

Abhishek Koladiya; Kara L Davis

doi:10.1016/j.cll.2023.05.004

Advances in Clinical Mass Cytometry

Clin Lab Med. 2023 Sep;43(3):507-519. doi: 10.1016/j.cll.2023.05.004. Epub 2023 Jun 20.

Authors

Abhishek Koladiya¹, Kara L Davis²

Affiliations

¹ Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
² Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; Center for Cancer Cell Therapy, Stanford University, Stanford, CA, USA. Electronic address: kardavis@stanford.edu.

PMID: 37481326
DOI: 10.1016/j.cll.2023.05.004

Abstract

The advent of high-dimensional single-cell technologies has enabled detection of cellular heterogeneity and functional diversity of immune cells during health and disease conditions. Because of its multiplexing capabilities and limited compensation requirements, mass cytometry or cytometry by time of flight (CyTOF) has played a superior role in immune monitoring compared with flow cytometry. Further, it has higher throughput and lower cost compared with other single-cell techniques. Several published articles have utilized CyTOF to identify cellular phenotypes and features associated with disease outcomes. This article introduces CyTOF-based assays to profile immune cell-types, cell-states, and their applications in clinical research.

Keywords: Clinical research; Cytometry; High-dimensional; Infectious disease; Mass cytometry; Neuroscience; Protein; Signaling.

Advances in Clinical Mass Cytometry

Authors

Affiliations

Abstract

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