Advanced software for MRgFUS treatment planning

Antria Filippou; Andreas Georgiou; Anastasia Nikolaou; Nikolas Evripidou; Christakis Damianou

doi:10.1016/j.cmpb.2023.107726

Advanced software for MRgFUS treatment planning

Comput Methods Programs Biomed. 2023 Oct:240:107726. doi: 10.1016/j.cmpb.2023.107726. Epub 2023 Jul 19.

Authors

Antria Filippou¹, Andreas Georgiou², Anastasia Nikolaou³, Nikolas Evripidou⁴, Christakis Damianou⁵

Affiliations

¹ Cyprus University of Technology, Department of Electrical Engineering, Computer Engineering, and Informatics, 30 Archbishop Kyprianou Str., Limassol 3036, Cyprus. Electronic address: ap.filippou@edu.cut.ac.cy.
² Cyprus University of Technology, Department of Electrical Engineering, Computer Engineering, and Informatics, 30 Archbishop Kyprianou Str., Limassol 3036, Cyprus.
³ Cyprus University of Technology, Department of Electrical Engineering, Computer Engineering, and Informatics, 30 Archbishop Kyprianou Str., Limassol 3036, Cyprus. Electronic address: ann.nikolaou@edu.cut.ac.cy.
⁴ Cyprus University of Technology, Department of Electrical Engineering, Computer Engineering, and Informatics, 30 Archbishop Kyprianou Str., Limassol 3036, Cyprus. Electronic address: nk.evripidou@edu.cut.ac.cy.
⁵ Cyprus University of Technology, Department of Electrical Engineering, Computer Engineering, and Informatics, 30 Archbishop Kyprianou Str., Limassol 3036, Cyprus. Electronic address: christakis.damianou@cut.ac.cy.

PMID: 37480647
DOI: 10.1016/j.cmpb.2023.107726

Abstract

Background and objectives: Herein, a user-friendly software platform for 3-dimensional Focused Ultrasound treatment planning based on Magnetic Resonance Imaging (MRI) images is presented.

Methods: The software directly retrieves and loads MRI images. Various design tools can be used on the MRI images to define the treatment area and the sonication parameters. Based on the treatment plan, the software controls the robotic motion and motion pattern of Magnetic Resonance guided Focused Ultrasound (MRgFUS) robotic systems to execute the treatment procedure. Real-time treatment monitoring is achieved through MRI images and thermometry. The software's functionality and performance were evaluated in both laboratory and MRI environments. Different treatment plans were designed on MRI images and sonications were executed on agar-based phantoms and polymer films.

Results: Magnetic Resonance (MR) thermometry maps were acquired in the agar-based phantoms. An exceptional agreement was observed between the software-planned treatment area and the lesions produced on the polymer films.

Conclusions: The developed software was successfully integrated with the MRI and robotic system controls for performing accurate treatment planning and real-time monitoring during sonications. The software provides an extremely user-friendly interface, while in the future it could be enhanced by providing dynamic modulation of the ultrasonic parameters during the treatment process.

Keywords: HIFU; MRgFUS; Software; Treatment planning.

MeSH terms

Agar
High-Intensity Focused Ultrasound Ablation*
Magnetic Resonance Imaging*
Polymers
Software

Substances

Agar
Polymers