A review of epidemiology and clinical relevance of Hepatitis B virus genotypes and subgenotypes

Jing Chen; Li Li; Qi Yin; Tao Shen

doi:10.1016/j.clinre.2023.102180

A review of epidemiology and clinical relevance of Hepatitis B virus genotypes and subgenotypes

Clin Res Hepatol Gastroenterol. 2023 Aug;47(7):102180. doi: 10.1016/j.clinre.2023.102180. Epub 2023 Jul 20.

Authors

Jing Chen¹, Li Li², Qi Yin¹, Tao Shen³

Affiliations

¹ Medical school, Kunming University of Science and Technology, Kunming, 650500, Yunnan Province, PR China; Department of Pulmonary and Critical Care Medicine, Yunnan Provincial Key Laboratory for Clinical Virology, Institute of Basic and Clinical Medicine, The First People's Hospital of Yunnan Province, Kunming, 650032, PR China.
² Department of Pulmonary and Critical Care Medicine, Yunnan Provincial Key Laboratory for Clinical Virology, Institute of Basic and Clinical Medicine, The First People's Hospital of Yunnan Province, Kunming, 650032, PR China.
³ Medical school, Kunming University of Science and Technology, Kunming, 650500, Yunnan Province, PR China; Department of Pulmonary and Critical Care Medicine, Yunnan Provincial Key Laboratory for Clinical Virology, Institute of Basic and Clinical Medicine, The First People's Hospital of Yunnan Province, Kunming, 650032, PR China; Department of Infectious Diseases and Hepatic Disease, Yunnan Province Innovation Team of Intestinal Microecology Related Disease Research and Technological Transformation, the First People's Hospital of Yunnan Province, Kunming 650032, PR China. Electronic address: ts902@hotmail.com.

PMID: 37479136
DOI: 10.1016/j.clinre.2023.102180

Abstract

Background: Hepatitis B virus (HBV) infection is a global public health burden, affecting nearly 300 million people around the world. Due to HBV population is considered to be represented as a viral quasispecies with genetic diversity, some reports showed that different genotypes of HBV have different viral effects, though the emergence of antiviral drugs that effectively inhibit viral replication, however, HBV infection has still not been eradicated and further research is needed.

Summary: HBV has been classified into at least ten genotypes (A-J) and more than 40 subgenotypes based on an intergroup or intragroup nucleotide difference across the whole genome, respectively. Inter genotypic recombinants were also observed during the HBV evolution. HBV genotypes and subgenotypes have distinct ethno-geographical distributions, as well as evident differences in their biological characteristics. HBV genotypes and subgenotypes also have close association with disease severity, long-term clinical outcomes, and response to antiviral therapy.

Keymessages: In this review, we up-dated the epidemiological characteristics, clinical features and prognosis of HBV infection with dissimilar genotype/subgenotypes, to better understanding and developing individualized prevention and treatment strategies.

Keywords: Antiviral therapy; Genotype; Hepatitis B virus; Subgenotype.

Publication types

Review

MeSH terms

Clinical Relevance
DNA, Viral
Genetic Variation
Genotype
Hepatitis B virus* / genetics
Hepatitis B* / genetics
Humans
Phylogeny

Substances

DNA, Viral