Unveiling the intricacies of intracellular Ca2+ regulation in the heart

Abstract

Recent studies have provided valuable insight into the key mechanisms contributing to the spatiotemporal regulation of intracellular Ca²⁺ release and Ca²⁺ signaling in the heart. In this research highlight, we focus on the latest findings published in Biophysical Journal examining the structural organization of Ca²⁺ handling proteins and assessing the functional aspects of intracellular Ca²⁺ regulation in health and the detrimental consequences of Ca²⁺ dysregulation in disease. These important studies pave the way for future mechanistic investigations and multiscale understanding of Ca²⁺ signaling in the heart.