Innate immune sensing by cGAS-STING in animals reveals unexpected messengers

Leonie Unterholzner

doi:10.1016/j.cell.2023.06.014

Innate immune sensing by cGAS-STING in animals reveals unexpected messengers

Cell. 2023 Jul 20;186(15):3145-3147. doi: 10.1016/j.cell.2023.06.014.

Author

Leonie Unterholzner¹

Affiliation

¹ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address: l.unterholzner@lancaster.ac.uk.

PMID: 37478819
DOI: 10.1016/j.cell.2023.06.014

Abstract

The DNA sensor cGAS and its adaptor STING constitute an ancient pathogen detection mechanism, but it is unclear to what extent its function is conserved across the animal kingdom. In this issue of Cell, Kranzusch and colleagues identify thousands of cGAS-like receptors and discover networks of second messengers that activate innate immune responses in animals.

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MeSH terms

Animals
Immunity, Innate
Membrane Proteins*
Nucleotidyltransferases / metabolism
Protein Serine-Threonine Kinases / metabolism
Signal Transduction* / physiology

Substances

Membrane Proteins
Nucleotidyltransferases
Protein Serine-Threonine Kinases