Synthesis of chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and antibacterial applications

Anandhavelu Sanmugam; S Abbishek; S Logesh Kumar; Ananda Babu Sairam; Vishnu Vardhan Palem; Raju Suresh Kumar; Abdulrahman I Almansour; Natarajan Arumugam; Dhanasekaran Vikraman

doi:10.1016/j.jmbbm.2023.106033

Synthesis of chitosan based reduced graphene oxide-CeO₂ nanocomposites for drug delivery and antibacterial applications

J Mech Behav Biomed Mater. 2023 Sep:145:106033. doi: 10.1016/j.jmbbm.2023.106033. Epub 2023 Jul 17.

Authors

Anandhavelu Sanmugam¹, S Abbishek², S Logesh Kumar³, Ananda Babu Sairam⁴, Vishnu Vardhan Palem⁵, Raju Suresh Kumar⁶, Abdulrahman I Almansour⁶, Natarajan Arumugam⁶, Dhanasekaran Vikraman⁷

Affiliations

¹ Department of Applied Chemistry, Sri Venkateswara College of Engineering, Pennalur, Sriperumpudur, 602117, Tamilnadu, India. Electronic address: sranand2204@gmail.com.
² Department of Chemical Engineering, Sri Venkateswara College of Engineering, Pennalur, Sriperumpudur, 602117, Tamilnadu, India.
³ Department of Biomedical Engineering, KPR Institute of Engineering and Technology, Coimbatore, India.
⁴ Department of Applied Chemistry, Sri Venkateswara College of Engineering, Pennalur, Sriperumpudur, 602117, Tamilnadu, India.
⁵ Research & Development, HBL Power Systems Ltd, Hyderabad, 500101, India.
⁶ Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
⁷ Division of Electronics and Electrical Engineering, Dongguk University-Seoul, 04620, South Korea.

PMID: 37478544
DOI: 10.1016/j.jmbbm.2023.106033

Abstract

In this study, the unique characteristics of chitosan, reduced graphene oxide (rGO) and cerium oxide (CeO₂) based hybrid bionano-composites make a carrier for various drug delivery and antimicrobial applications. The recent literatures shown that addition of biopolymers to rGO and CeO₂ based nanocomposites exhibit excellent performance in design and development of biosensors, wound dressings, electrodes, microfluidic chips, drug delivery systems and energy storage applications. Chitosan (CS), reduced graphene oxide (rGO) mixed with cerium oxide (CeO₂) to form CS-rGO and CS-rGO-CeO₂ hybrid bionano-composites using precipitation method. The physiochemical characterization of casted nanocomposite sheet was done using FTIR, XRD, UV-Vis spectrum, SEM and TGA. The XRD results of CS-rGO-CeO₂ revealed that the nanoparticle was found to be crystalline structure. FTIR revealed that nitrogen functionalities of CS interacted with rGO-CeO₂ to form hybrid nanocomposites. The thermal gravimetric analysis (TGA) showed that the CS-rGO-CeO₂ has better thermal stability up to 550 °C. The SEM confirms the surface morphology of CS-rGO-CeO₂ has large surface area with smooth surface. Moreover, the antibacterial properties of nanocomposites exhibit excellent zone of inhibition against Staphylococcus aureus and Escherichia coli. The NIH3T3 cell line evaluations showed superior cell adhesion on hybrid nanocomposites. Hence bionano-composite based on CS, rGO and CeO₂ are potential biomaterials for drug delivery and antibacterial applications.

Keywords: Antibacterial; Cerium Oxide; Chitosan; Drug delivery; Reduced Graphene Oxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Chitosan* / chemistry
Drug Delivery Systems
Graphite* / chemistry
Mice
NIH 3T3 Cells
Nanocomposites* / chemistry

Substances

Chitosan
graphene oxide
ceric oxide
Graphite
Anti-Bacterial Agents