Enhancing bioavailability of natural extracts for nutritional applications through dry powder inhalers (DPI) spray drying: technological advancements and future directions

Bo Wang; Jia Xiang; Binsheng He; Songwen Tan; Wenhu Zhou

doi:10.3389/fnut.2023.1190912

Enhancing bioavailability of natural extracts for nutritional applications through dry powder inhalers (DPI) spray drying: technological advancements and future directions

Front Nutr. 2023 Jul 5:10:1190912. doi: 10.3389/fnut.2023.1190912. eCollection 2023.

Authors

Bo Wang^{1

2}, Jia Xiang^{1

2}, Binsheng He¹, Songwen Tan^{1

2}, Wenhu Zhou^{1

2}

Affiliations

¹ Academician Workstation, Changsha Medical University, Changsha, China.
² Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.

Abstract

Natural ingredients have many applications in modern medicine and pharmaceutical projects. However, they often have low solubility, poor chemical stability, and low bioavailability in vivo. Spray drying technology can overcome these challenges by enhancing the properties of natural ingredients. Moreover, drug delivery systems can be flexibly designed to optimize the performance of natural ingredients. Among the various drug delivery systems, dry powder inhalation (DPI) has attracted much attention in pharmaceutical research. Therefore, this review will focus on the spray drying of natural ingredients for DPI and discuss their synthesis and application.

Keywords: application of natural extracts; dry powder inhalation; factors influencing DPI; natural ingredients; spray drying.

Publication types

Review

Grants and funding

This research was supported by Changsha Medical University.