Ginsenosides on stem cells fate specification-a novel perspective

Ying Liu; Leilei Jiang; Wenbo Song; Chenxi Wang; Shiting Yu; Juhui Qiao; Xinran Wang; Chenrong Jin; Daqing Zhao; Xueyuan Bai; Peiguang Zhang; Siming Wang; Meichen Liu

doi:10.3389/fcell.2023.1190266

Ginsenosides on stem cells fate specification-a novel perspective

Front Cell Dev Biol. 2023 Jul 5:11:1190266. doi: 10.3389/fcell.2023.1190266. eCollection 2023.

Authors

Affiliations

¹ Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
² Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences Changchun, Changchun, Jilin, China.

Abstract

Recent studies have demonstrated that stem cells have attracted much attention due to their special abilities of proliferation, differentiation and self-renewal, and are of great significance in regenerative medicine and anti-aging research. Hence, finding natural medicines that intervene the fate specification of stem cells has become a priority. Ginsenosides, the key components of natural botanical ginseng, have been extensively studied for versatile effects, such as regulating stem cells function and resisting aging. This review aims to summarize recent progression regarding the impact of ginsenosides on the behavior of adult stem cells, particularly from the perspective of proliferation, differentiation and self-renewal.

Keywords: differentiation; fate specification; ginsenosides; proliferation; self-renewal; stem cells.

Publication types

Review

Grants and funding

This research was funded by the Scientific and Technological Development Planning Foundation of Jilin Province (YDZJ202201ZYTS683), the Scientific and Technological Developing Scheme of Ji Lin Province (20210204188YY), and the National Natural Science Foundation of China (U19A2013).