The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis

Veronica Ghini; Michele Mannelli; Lara Massai; Andrea Geri; Stefano Zineddu; Tania Gamberi; Luigi Messori; Paola Turano

doi:10.1039/d3ra04032a

The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis

RSC Adv. 2023 Jul 19;13(31):21629-21632. doi: 10.1039/d3ra04032a. eCollection 2023 Jul 12.

Authors

Veronica Ghini^{1

2}, Michele Mannelli³, Lara Massai¹, Andrea Geri¹, Stefano Zineddu^{1

2}, Tania Gamberi³, Luigi Messori¹, Paola Turano^{1

2

4}

Affiliations

¹ Department of Chemistry "Ugo Schiff", University of Florence Sesto Fiorentino 50019 Italy luigi.messori@unifi.it paola.turano@unifi.it.
² Magnetic Resonance Center (CERM), University of Florence Sesto Fiorentino 50019 Italy.
³ Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence Florence 50134 Italy.
⁴ Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) Sesto Fiorentino 50019 Italy.

Abstract

NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.