Emerging roles of microRNAs in septic cardiomyopathy

Mingyan Wu; Guangdong Li; Wenjun Wang; Hongsheng Ren

doi:10.3389/fphar.2023.1181372

Emerging roles of microRNAs in septic cardiomyopathy

Front Pharmacol. 2023 Jul 5:14:1181372. doi: 10.3389/fphar.2023.1181372. eCollection 2023.

Authors

Mingyan Wu¹, Guangdong Li¹, Wenjun Wang¹, Hongsheng Ren¹

Affiliation

¹ Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Abstract

As one of the serious complications of sepsis, septic cardiomyopathy has gained more and more attention, because of its high morbidity and mortality. With the in-depth study of septic cardiomyopathy, several methods have been adopted clinically but have poor therapeutic effects due to failure to find precise therapeutic targets. In recent years, microRNAs have been found to be related to the pathogenesis, diagnosis, and treatment of septic cardiomyopathy via regulating immunity and programmed cell death. This paper reviews the role of microRNAs in septic cardiomyopathy, aiming to provide new targets for the diagnosis and treatment of septic cardiomyopathy.

Keywords: apoptosis; autophage; inflammation; microRNA; pyroptosis; septic cardiomyopathy.

Publication types

Review

Grants and funding

This work was supported by the Shandong Provincial Research and Development Plan (item 2016 GSF 201052), National Natural Science Foundation of China (Grant No. 82202376) and Shandong Provincial Natural Science Foundation (Grant No. ZR2022QH225).