Objectives: To analyze the clinicopathological features of maxillofacial granular cell tumors (GCT) with the aid of immunohistochemical staining.
Methods: Seven cases of maxillofacial GCT were retrospectively collated, and the microscopic morphology of maxillofacial GCT was analyzed. The expression of S-100, neuron-specific enolase (NSE), SOX-10, CD68, actin, desmin, and Ki-67 in GCT was detected by immunohistochemical staining. The cases were observed in the follow-ups after clinical treatment.
Results: All seven GCT tumors lacked envelopes and were poorly defined. Microscopically, the sizes of the tumor cells were large and appeared with inconspicuous cell membranes, forming a syncytium-like appearance. The cytoplasm was filled with characteristic eosinophilic granules. The immunohistochemical results showed that six cases were NSE-positive, five cases were S-100-positive, seven cases were CD68-positive, five cases were SOX-10-positive, one case was actin-positive, and seven cases were desmin-negative. The Ki-67 index did not exceed 5% in all cases. In the follow-up sessions, none of the six cases presented a recurrence.
Conclusions: Maxillofacial GCT has a characteristic histological structure. Immunohistochemical S-100, CD68, and other indicators can assist in diagnosis, and the prognosis is good after clinical resection.
目的: 借助免疫组织化学染色分析探讨颌面部颗粒细胞瘤（GCT）的临床组织病理特征。方法: 回顾性纳入7例颌面部GCT，分析颌面部GCT的镜下形态，免疫组织化学染色检测S-100、神经元特异性烯醇酶、SOX-10、CD68、肌动蛋白、结蛋白与Ki-67在GCT中的表达情况，并随访治疗效果。结果: 7例颌面部GCT肿瘤皆缺乏包膜，边界不清。镜下肿瘤细胞胞质内充满特征性嗜酸性颗粒。免疫组织化学结果显示，6例NSE阳性，5例S-100阳性，7例CD68阳性，5例SOX-10阳性，1例肌动蛋白阳性，7例结蛋白阴性，Ki-67阳性比例均不超过5%。随访的6例颌面部GCT均未复发。结论: 颌面部GCT具有特征性组织学结构，免疫组织化学S-100、CD68等指标可辅助诊断，临床切除后预后良好。.
Keywords: clinicopathology; granular cell tumor; immunohistochemistry.