Recent advances towards mass spectrometry-based clinical lipidomics

Samira Salihovic; Santosh Lamichane; Tuulia Hyötyläinen; Matej Orešič

doi:10.1016/j.cbpa.2023.102370

Recent advances towards mass spectrometry-based clinical lipidomics

Curr Opin Chem Biol. 2023 Oct:76:102370. doi: 10.1016/j.cbpa.2023.102370. Epub 2023 Jul 18.

Authors

Samira Salihovic¹, Santosh Lamichane², Tuulia Hyötyläinen³, Matej Orešič⁴

Affiliations

¹ School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
² Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
³ School of Science and Technology, Örebro University, Örebro, Sweden.
⁴ School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. Electronic address: matej.oresic@oru.se.

PMID: 37473482
DOI: 10.1016/j.cbpa.2023.102370

Abstract

The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging patterns in utilizing lipidomics in clinical research.In this review, we assess the recent advancements in lipidomics methodologies that exhibit high levels of selectivity and sensitivity, capable of generating numerous molecular lipid species from limited quantities of biological matrices. The reviewed studies demonstrate that molecular lipid signatures offer new opportunities for precision medicine by providing sensitive diagnostic tools for disease prediction and monitoring. Moreover, the latest innovations in microsampling techniques have the potential to make a substantial contribution to clinical lipidomics. The review also shows that more work is needed to harmonize results across diverse lipidomics platforms and avoid significant errors in analysis and reporting. The increased implementation of internal standards and standard reference materials in analytical workflows will aid in this direction.

Keywords: Biomarkers; Human health; Lipidomics; Mass spectrometry; Microsampling.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Lipid Metabolism
Lipidomics*
Lipids* / analysis
Mass Spectrometry
Workflow

Substances

Lipids