This study aimed to investigate the hypoglycaemic and hypolipidemic activities of total flavonoids from Nymphaea candida (NCTF). The result showed that NCTF could significantly ameliorate various indicators such as FBG, OGTT, TC, TG, LDL-C, and HDL-C in ALX-induced diabetic mice compared with the model group. Meanwhile, in the therapeutical effect study of NCTF on high-fat and high-sugar diets combined with STZ-induced T2DM mice, all parameters including RBG, INS, and INSR related to diabetes were significantly improved by NCTF as well as the serum ALT, AST, ALP, CR, MDA, and IL-6 activities. NCTF could significantly increase the expression levels of SOD and PPAR-γ in T2DM. Pathological observation showed that NCTF could improve the damage to pancreatic and liver tissues in T2DM mice. In conclusion, NCTF has better hypoglycaemic and hypolipidemic effects, and its mechanism may be related to its antioxidant, PPAR-γ regulation, and inhibiting inflammatory cytokine expression.
Keywords: Nymphaea candida; T2DM; diabetes; flavonoids; hypoglycaemic and hypolipidemic activities.