Delivery of Oleanolic Acid with Improved Antifibrosis Efficacy by a Cell Penetrating Peptide P10

Lidan Wang; Jingping Geng; Hu Wang

doi:10.1021/acsptsci.3c00087

Delivery of Oleanolic Acid with Improved Antifibrosis Efficacy by a Cell Penetrating Peptide P10

ACS Pharmacol Transl Sci. 2023 Jun 30;6(7):1006-1014. doi: 10.1021/acsptsci.3c00087. eCollection 2023 Jul 14.

Authors

Lidan Wang^{1

2}, Jingping Geng^{1

3}, Hu Wang^{1

4}

Affiliations

¹ Department of Microbiology and Immunology, Medical School, China Three Gorges University, Yichang 443002, China.
² Laboratory Medicine Department, Chinese Medicine Hospital of Puyang, Puyang 457000, China.
³ Interdisciplinary Laboratory of Molecular Biology and Biophysics, Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warszawa, Poland.
⁴ Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21215, United States.

PMID: 37470025
PMCID: PMC10353059 (available on 2024-06-30)
DOI: 10.1021/acsptsci.3c00087

Abstract

Oleanolic acid (OA), a common pentacyclic triterpenoid found in plants, has several therapeutic uses, including the treatment of hepatopathy disorders. However, due to OA's weak permeability and limited bioavailability, its therapeutic advantages are limited. Here, we showed that a short peptide known as p10 not only binds to OA but also rapidly enhances OA delivery into cultured hepatic stellate cells (HSCs), lowers their synthesis of fibrogenic proteins, and further reduces the HSC migration capacity. Our findings show that noncovalently conjugating short peptides to OA improves its pharmacological efficacy and permeability.