Crosstalk between ferroptosis and steroid hormone signaling in gynecologic cancers

Wen Lai; Jianquan Chen; Tianming Wang; Qiaoling Liu

doi:10.3389/fmolb.2023.1223493

Crosstalk between ferroptosis and steroid hormone signaling in gynecologic cancers

Front Mol Biosci. 2023 Jul 4:10:1223493. doi: 10.3389/fmolb.2023.1223493. eCollection 2023.

Authors

Wen Lai¹, Jianquan Chen², Tianming Wang², Qiaoling Liu¹

Affiliations

¹ Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China.
² Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China.

Abstract

Ferroptosis is a novel types of regulated cell death and is widely studied in cancers and many other diseases in recent years. It is characterized by iron accumulation and intense lipid peroxidation that ultimately inducing oxidative damage. So far, signaling pathways related to ferroptosis are involved in all aspects of determining cell fate, including oxidative phosphorylation, metal-ion transport, energy metabolism and cholesterol synthesis progress, et al. Recently, accumulated studies have demonstrated that ferroptosis is associated with gynecological oncology related to steroid hormone signaling. This review trends to summarize the mechanisms and applications of ferroptosis in cancers related to estrogen and progesterone, which is expected to provide a theoretical basis for the prevention and treatment of gynecologic cancers.

Keywords: estrogen; ferroptosis; gynecologic cancers; lipid peroxidation; progesterone.

Publication types

Review

Grants and funding

This work is supported by Open Project of Jiangsu Biobank of Clinical Resources (Grant/Award Number: TC2021B013) and the Nanjing Healthcare Science and Technology Development Special Funded Project (Grant/Award Number: YKK20197).