Engineered biomimetic micro/nano-materials for tissue regeneration

Feng Han; Qingchen Meng; En Xie; Kexin Li; Jie Hu; Qianglong Chen; Jiaying Li; Fengxuan Han

doi:10.3389/fbioe.2023.1205792

Engineered biomimetic micro/nano-materials for tissue regeneration

Front Bioeng Biotechnol. 2023 Jul 4:11:1205792. doi: 10.3389/fbioe.2023.1205792. eCollection 2023.

Authors

Feng Han¹, Qingchen Meng¹, En Xie¹, Kexin Li¹, Jie Hu¹, Qianglong Chen¹, Jiaying Li¹, Fengxuan Han^{1

2}

Affiliations

¹ Department of Orthopaedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, China.
² China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, Zhejiang, China.

Abstract

The incidence of tissue and organ damage caused by various diseases is increasing worldwide. Tissue engineering is a promising strategy of tackling this problem because of its potential to regenerate or replace damaged tissues and organs. The biochemical and biophysical cues of biomaterials can stimulate and induce biological activities such as cell adhesion, proliferation and differentiation, and ultimately achieve tissue repair and regeneration. Micro/nano materials are a special type of biomaterial that can mimic the microstructure of tissues on a microscopic scale due to its precise construction, further providing scaffolds with specific three-dimensional structures to guide the activities of cells. The study and application of biomimetic micro/nano-materials have greatly promoted the development of tissue engineering. This review aims to provide an overview of the different types of micro/nanomaterials, their preparation methods and their application in tissue regeneration.

Keywords: biomimetic microstructure; micro/nano-materials; regeneration; repair; tissue engineering.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (32130059 and 32171350), Medical and Health Science and Technology Innovation Project of Suzhou (SKY2022105), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.