Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription

Jingjie Zhang; Xianmei Meng; Yi Zhou; Zhengyu Jiang; Hongsuo Chen; Zhiyi Meng; Qi Zhang; Weichang Chen

doi:10.1186/s12935-023-02986-8

Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription

Cancer Cell Int. 2023 Jul 19;23(1):142. doi: 10.1186/s12935-023-02986-8.

Authors

Jingjie Zhang^#^{1

2}, Xianmei Meng^#², Yi Zhou², Zhengyu Jiang², Hongsuo Chen², Zhiyi Meng², Qi Zhang^{1

3}, Weichang Chen⁴

Affiliations

¹ Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, P. R. China.
² Center of Digestive Endoscopy, The Second Affiliated Hospital of Baotou Medical College, Baotou, 014000, Inner Mongolia, China.
³ Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
⁴ Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, P. R. China. sdfyywcc@126.com.

^# Contributed equally.

Abstract

Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4 could promote the proliferation and metastasis of CRC cells. These consequences were achieved by lnc-LRRTM4 directly binding to the promoter of LRRTM4 to induce its transcription. Moreover, lnc-LRRTM4 enhanced the growth of CRC cells in vivo by promoting cell cycle progression and reducing apoptosis. Taken together, our results revealed that lnc-LRRTM4 promotes the proliferation and metastasis of CRC cells, suggesting that it may be a potential diagnostic and therapeutic target for CRC.

Keywords: CRC; EMT; LRRTM4; Long noncoding RNA; lnc-LRRTM4.