Plasma protein biomarkers trailblaze as early predictors of type 1 diabetes

Xiaojing Jia; Shuangyuan Wang; Jieli Lu

doi:10.1016/j.xcrm.2023.101116

Plasma protein biomarkers trailblaze as early predictors of type 1 diabetes

Cell Rep Med. 2023 Jul 18;4(7):101116. doi: 10.1016/j.xcrm.2023.101116.

Authors

Xiaojing Jia¹, Shuangyuan Wang¹, Jieli Lu²

Affiliations

¹ Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jielilu@hotmail.com.

Abstract

Nakayasu et al.'s investigation¹ on children from TEDDY study revealed robust predictive value of plasma protein biomarkers in identifying the emergence of persistent autoantibodies and type 1 diabetes. Remarkably, this predictive accuracy was observed six months prior to autoimmunity initiation.

MeSH terms

Autoantibodies
Autoimmunity
Biomarkers
Child
Diabetes Mellitus, Type 1* / diagnosis
Humans
Islets of Langerhans* / metabolism

Substances

Autoantibodies
Biomarkers