Disparities in post-mastectomy reconstruction use among American Indian and Alaska Native women

McKenzie J White; Saranya Prathibha; Corinne Praska; Jacob S Ankeny; Christopher J LaRocca; Mary J Owen; Madhuri Rao; Todd M Tuttle; Schelomo Marmor; Jane Y C Hui

doi:10.1097/PRS.0000000000010935

Disparities in post-mastectomy reconstruction use among American Indian and Alaska Native women

Plast Reconstr Surg. 2023 Jul 18. doi: 10.1097/PRS.0000000000010935. Online ahead of print.

Authors

McKenzie J White¹, Saranya Prathibha¹, Corinne Praska², Jacob S Ankeny^{1

3}, Christopher J LaRocca^{1

3}, Mary J Owen⁴, Madhuri Rao^{1

3}, Todd M Tuttle^{1

3}, Schelomo Marmor^{1

3

5}, Jane Y C Hui^{1

3}

Affiliations

¹ Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis MN 55455, USA.
² Department of Surgery, University of Wisconsin School of Medicine and Public Health, Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792-7375.
³ Masonic Cancer Center, University of Minnesota, 420 Delaware St SE, MMC 806, Minneapolis MN 55455, USA.
⁴ Center of American Indian and Minority Health, University of Minnesota Duluth,182 SMed,1035 University Dr. Duluth, MN 55812.
⁵ Center for Clinical Quality & Outcomes Discovery & Evaluation (C-QODE), University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis MN 55455, USA.

PMID: 37467081
DOI: 10.1097/PRS.0000000000010935

Abstract

Background: American Indian/Alaska Native (AI/AN) breast cancer patients undergo post-mastectomy reconstruction (PMR) infrequently relative to Non-Hispanic White (NHW) patients. Factors associated with low PMR rates among AI/AN are poorly understood. We sought to describe factors associated with this disparity in surgical care.

Methods: A retrospective cohort study of the National Cancer Database (2004 - 2017) identified AI/AN and NHW women, ages 18 - 64, who underwent mastectomy for stage 0 - III breast cancer. Patient characteristics, annual PMR rates, and factors associated with PMR were described with univariable analysis, the Cochran-Armitage test, and multivariable logistical regression.

Results: 414,036 NHW and 1,980 AI/AN met inclusion criteria. Relative to NHW, AI/AN had more comorbidities (20% vs 12% Charlson Comorbidity Index ≥ 1, p < 0.001), had non-private insurance (49% vs 20%, p < 0.001), and underwent unilateral mastectomy more frequently (69% vs 61%, p < 0.001). PMR rates increased over the study period, from 13% to 47% for AI/AN and from 29% to 62% for NHW (p <0.001). AI/AN race was independently associated with decreased likelihood of PMR (OR 0.62, 95% CI 0.56-0.69). Among AI/AN, decreased likelihood of PMR was significantly associated with older age at diagnosis, more remote year of diagnosis, advanced disease (tumor size > 5 cm, positive lymph nodes), unilateral mastectomy, non-private insurance, and lower educational attainment in patient's area of residence.

Conclusion: PMR rates among AI/AN with stage 0 - III breast cancer have increased, yet remain significantly lower than among NHW. Further research should elicit AI/AN perspectives on PMR, and guide early breast cancer detection and treatment.