A trade-off between ligand coating and crystallinity of Gd-doped ultrasmall CeO2 for improving relaxivity

Qian Ma; Hui Wang; Qiangqiang Nie; Suying Xu; Leyu Wang

doi:10.1039/d3cc02095a

A trade-off between ligand coating and crystallinity of Gd-doped ultrasmall CeO₂ for improving relaxivity

Chem Commun (Camb). 2023 Aug 3;59(63):9654-9657. doi: 10.1039/d3cc02095a.

Authors

Qian Ma¹, Hui Wang¹, Qiangqiang Nie², Suying Xu¹, Leyu Wang¹

Affiliations

¹ State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China. lywang@mail.buct.edu.cn.
² Department of Cardiovascular Surgery, China-Japan Friendship Hospital, Beijing, China.

PMID: 37466352
DOI: 10.1039/d3cc02095a

Abstract

A Gd-doped ultrasmall CeO₂ contrast agent was prepared with high longitudinal relaxivity (r₁ = 10.1 mM^-1 s^-1, 7.0 T) through rationally regulating the crystallinity and surface coatings, providing a new paradigm for optimizing MRI performance. Moreover, responsive photoacoustic imaging (PAI) was established via tumor microenvironment-triggered oxidation, affording dual-modal imaging.