Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

Xue Yang; Ying Wang; Valentina Rovella; Eleonora Candi; Wei Jia; Francesca Bernassola; Pierluigi Bove; Mauro Piacentini; Manuel Scimeca; Giuseppe Sica; Giuseppe Tisone; Alessandro Mauriello; Lixin Wei; Gerry Melino; Yufang Shi

doi:10.1186/s13062-023-00394-6

Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

Biol Direct. 2023 Jul 18;18(1):40. doi: 10.1186/s13062-023-00394-6.

Authors

Xue Yang^#^{1

2}, Ying Wang^#², Valentina Rovella^#¹, Eleonora Candi¹, Wei Jia^{3

4}, Francesca Bernassola¹, Pierluigi Bove¹, Mauro Piacentini¹, Manuel Scimeca¹, Giuseppe Sica¹, Giuseppe Tisone¹, Alessandro Mauriello¹, Lixin Wei⁵, Gerry Melino⁶, Yufang Shi⁷

Affiliations

¹ Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
² The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, China.
³ Center for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
⁴ School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
⁵ Department of Tumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China.
⁶ Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy. melino@uniroma2.it.
⁷ The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, China. yufangshi@sibs.ac.cn.

^# Contributed equally.

Abstract

Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and "inflammaging". Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the "inflammaging" and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.

Keywords: Inflammation; MSC Therapy; Mesenchymal stem cells.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cell Differentiation / physiology
Humans
Inflammation* / therapy
Mesenchymal Stem Cells*