On the Correlations of Gray Matter with Schizotypy in Mentally Healthy Subjects

I S Lebedeva; A S Tomyshev; E V Pechenkova

doi:10.1007/s10517-023-05852-9

On the Correlations of Gray Matter with Schizotypy in Mentally Healthy Subjects

Bull Exp Biol Med. 2023 Jun;175(2):291-294. doi: 10.1007/s10517-023-05852-9. Epub 2023 Jul 18.

Authors

I S Lebedeva¹, A S Tomyshev², E V Pechenkova³

Affiliations

¹ Scientific Center of Mental Health, Moscow, Russia. lebedeva-i@yandex.ru.
² Scientific Center of Mental Health, Moscow, Russia.
³ National Research University Higher School of Economics (HSE University), Moscow, Russia.

PMID: 37464196
DOI: 10.1007/s10517-023-05852-9

Abstract

We analyzed the relationships between morphometric characteristics of brain gray matter and schizotypy. Mentally healthy subjects (n=164, age 18-35 years) completed Russian version of SPQ-74 test and underwent high-field 3T MRI. Cortical thickness in the right frontal pole (determined with FreeSurfer 6.0.0) positively correlated with negative schizotypy factor. The revealed features can reflect the protective mechanisms (resilience) against the development of mental disorders and also can be a result of individual ontogenesis trajectories manifested in deceleration of the decrease of the cortex thickness during first 3 decades of life.

Keywords: SPQ-74; magnetic resonance imaging (MRI); morphometry; schizotypy.

MeSH terms

Adolescent
Adult
Frontal Lobe
Gray Matter* / diagnostic imaging
Healthy Volunteers
Humans
Magnetic Resonance Imaging
Schizotypal Personality Disorder* / diagnostic imaging
Young Adult