The beauty and complexity of the small heat shock proteins: a report on the proceedings of the fourth workshop on small heat shock proteins

Heath Ecroyd; Britta Bartelt-Kirbach; Anat Ben-Zvi; Raffaella Bonavita; Yevheniia Bushman; Elena Casarotto; Ciro Cecconi; Wilson Chun Yu Lau; Jonathan D Hibshman; Joep Joosten; Virginia Kimonis; Rachel Klevit; Krzysztof Liberek; Kathryn A McMenimen; Tsukumi Miwa; Axel Mogk; Daniele Montepietra; Carsten Peters; Maria Teresa Rocchetti; Dominik Saman; Angela Sisto; Valentina Secco; Annika Strauch; Hideki Taguchi; Morgan Tanguay; Barbara Tedesco; Melinda E Toth; Zihao Wang; Justin L P Benesch; Serena Carra

doi:10.1007/s12192-023-01360-x

The beauty and complexity of the small heat shock proteins: a report on the proceedings of the fourth workshop on small heat shock proteins

Cell Stress Chaperones. 2023 Nov;28(6):621-629. doi: 10.1007/s12192-023-01360-x. Epub 2023 Jul 18.

Authors

Heath Ecroyd¹, Britta Bartelt-Kirbach², Anat Ben-Zvi³, Raffaella Bonavita⁴, Yevheniia Bushman⁵, Elena Casarotto⁶, Ciro Cecconi^{7

8}, Wilson Chun Yu Lau⁹, Jonathan D Hibshman¹⁰, Joep Joosten^{11

12}, Virginia Kimonis^{13

14}, Rachel Klevit¹⁵, Krzysztof Liberek¹⁶, Kathryn A McMenimen¹⁷, Tsukumi Miwa¹⁸, Axel Mogk¹⁹, Daniele Montepietra^{8

20}, Carsten Peters⁵, Maria Teresa Rocchetti²¹, Dominik Saman^{22

23}, Angela Sisto²⁴, Valentina Secco²⁵, Annika Strauch⁵, Hideki Taguchi¹⁸, Morgan Tanguay¹⁷, Barbara Tedesco⁶, Melinda E Toth²⁶, Zihao Wang^{22

23}, Justin L P Benesch^{27

28}, Serena Carra²⁹

Affiliations

¹ Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia. heath_ecroyd@uow.edu.au.
² Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.
³ Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
⁴ Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131, Naples, Italy.
⁵ Center for Protein Assemblies and Department Chemie, Technische Universität München, München, Germany.
⁶ Dipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti" (DiSFeB), Dipartimento di Eccellenza, Università degli Studi di Milano, Milan, Italy.
⁷ Department of Physics, Informatics and Mathematics, University of Modena and Reggio Emilia, Modena, Italy.
⁸ Istituto Nanoscienze-CNR-NANO, Center S3, Modena, Italy.
⁹ State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
¹⁰ Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
¹¹ Department of Synthetic Organic Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
¹² Department of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
¹³ Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California - Irvine, Orange, CA, 92868, USA.
¹⁴ Department of Neurology and Department of Pathology, University of California, Irvine, CA, 92697, USA.
¹⁵ Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, 98195, USA.
¹⁶ Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk, Poland.
¹⁷ Program in Biochemistry and Department of Chemistry, Mount Holyoke College, South Hadley, MA, 01075, USA.
¹⁸ Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8503, Japan.
¹⁹ Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld, 282, Heidelberg, Germany.
²⁰ Department of Department of Chemical, Life and Environmental sustainability sciences, University of Parma, Parma, Italy.
²¹ Department of Clinical and Experimental Medicine, University of Foggia, 71122, Foggio, Italy.
²² Department of Chemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.
²³ Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
²⁴ Peripheral Neuropathy Research Group, Department of Biomedical Sciences and Institute Born Bunge, University of Antwerp, Antwerpen, Belgium.
²⁵ Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
²⁶ Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Temesvári krt. 62, Szeged, H-6726, Hungary.
²⁷ Department of Chemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK. justin.benesch@chem.ox.ac.uk.
²⁸ Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. justin.benesch@chem.ox.ac.uk.
²⁹ Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. serena.carra@unimore.it.

Abstract

The Fourth Cell Stress Society International workshop on small heat shock proteins (sHSPs), a follow-up to successful workshops held in 2014, 2016 and 2018, took place as a virtual meeting on the 17-18 November 2022. The meeting was designed to provide an opportunity for those working on sHSPs to reconnect and discuss their latest work. The diversity of research in the sHSP field is reflected in the breadth of topics covered in the talks presented at this meeting. Here we summarise the presentations at this meeting and provide some perspectives on exciting future topics to be addressed in the field.

Keywords: Cellular stress; Molecular chaperones; Protein aggregation; Protein folding; Protein homeostasis; Small heat shock proteins.

Publication types

Review

MeSH terms

Heat-Shock Proteins, Small* / metabolism
Proteins

Substances

Heat-Shock Proteins, Small
Proteins

Grants and funding

R01 EY017370/EY/NEI NIH HHS/United States