Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

Dhammika Leshan Wannigama; Mohan Amarasiri; Phatthranit Phattharapornjaroen; Cameron Hurst; Charin Modchang; Sudarat Chadsuthi; Suparinthon Anupong; Kazuhiko Miyanaga; Longzhu Cui; Wanwara Thuptimdang; S M Ali Hosseini Rad; Stefan Fernandez; Angkana T Huang; Porames Vatanaprasan; Dylan John Jay; Thammakorn Saethang; Sirirat Luk-In; Robin James Storer; Puey Ounjai; Naveen Kumar Devanga Ragupathi; Phitsanuruk Kanthawee; Daisuke Sano; Takashi Furukawa; Kazunari Sei; Asada Leelahavanichkul; Talerngsak Kanjanabuch; Paul G Higgins; Asuka Nanbo; Anthony Kicic; Andrew C Singer; Tanittha Chatsuwan; Sam Trowsdale; Richard Siow; Kenji Shibuya; Shuichi Abe; Hitoshi Ishikawa; Parichart Hongsing

doi:10.1093/jtm/taad096

Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

J Travel Med. 2023 Sep 5;30(5):taad096. doi: 10.1093/jtm/taad096.

Authors

Dhammika Leshan Wannigama^{1

2

3

4

5

6}, Mohan Amarasiri⁷, Phatthranit Phattharapornjaroen^{8

9}, Cameron Hurst^{10

11}, Charin Modchang^{12

13

14}, Sudarat Chadsuthi¹⁵, Suparinthon Anupong¹², Kazuhiko Miyanaga¹⁶, Longzhu Cui¹⁶, Wanwara Thuptimdang¹⁷, S M Ali Hosseini Rad^{18

19}, Stefan Fernandez²⁰, Angkana T Huang²⁰, Porames Vatanaprasan¹⁶, Dylan John Jay⁶, Thammakorn Saethang²¹, Sirirat Luk-In²², Robin James Storer²³, Puey Ounjai²⁴, Naveen Kumar Devanga Ragupathi^{4

5}, Phitsanuruk Kanthawee²⁵, Daisuke Sano^{26

27}, Takashi Furukawa⁷, Kazunari Sei⁷, Asada Leelahavanichkul^{2

28}, Talerngsak Kanjanabuch^{29

30

31

32}, Paul G Higgins^{33

34

35}, Asuka Nanbo³⁶, Anthony Kicic^{37

38

39

40}, Andrew C Singer⁴¹, Tanittha Chatsuwan^{2

3}, Sam Trowsdale⁴², Richard Siow^{43

44

45}, Kenji Shibuya⁴⁶, Shuichi Abe¹, Hitoshi Ishikawa⁴⁷, Parichart Hongsing^{48

49}

Affiliations

¹ Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Aoyagi, Yamagata, Japan.
² Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Pathum Wan, Bangkok, Thailand.
³ Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok, Thailand.
⁴ School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, Western Australia, Australia.
⁵ Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries, The University of Sheffield, Sheffield, South Yorkshire, UK.
⁶ Pathogen Hunter's Research Collaborative Team, Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Aoyagi, Yamagata, Japan.
⁷ Laboratory of Environmental Hygiene, Department of Health Science, School of Allied Health Sciences/Graduate School of Medical Sciences, Kitasato University, Sagamihara-Minami, Kanagawa, Japan.
⁸ Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Bangkok, Thailand.
⁹ Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Academy, Gothenburg University, Universitetsplatsen 1, 405 30 Gothenburg, Sweden.
¹⁰ Molly Wardaguga Research Centre, Charles Darwin University, Brisbane, Queensland, Australia.
¹¹ Statistics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
¹² Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok, Thailand.
¹³ Centre of Excellence in Mathematics, MHESI, Ratchathewi, Bangkok, Thailand.
¹⁴ Thailand Center of Excellence in Physics, Ministry of Higher Education, Science, Research and Innovation, Ratchathewi, Bangkok, Thailand.
¹⁵ Department of Physics, Faculty of Science, Naresuan University, Mueang Phitsanulok District, Phitsanulok, Thailand.
¹⁶ Division of Bacteriology, School of Medicine, Jichi Medical University, Tochigi, Japan.
¹⁷ Institute of Biomedical Engineering, Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
¹⁸ Department of Microbiology and Immunology, University of Otago, Dunedin, Otago, New Zealand.
¹⁹ Center of Excellence in Immunology and Immune-Mediated Diseases, Chulalongkorn University, Pathum Wan Bangkok, Thailand.
²⁰ Department of Virology, U.S. Army Medical Directorate, Armed Forces Research Institute of Medical Sciences, Ratchathewi, Bangkok, Thailand.
²¹ Department of Computer Science, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, Thailand.
²² Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Phutthamonthon District, Nakhon Pathom, Thailand.
²³ Office of Research Affairs, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok, Thailand.
²⁴ Department of Biology, Faculty of Science, Mahidol University, Ratchathewi, Bangkok, Thailand.
²⁵ Public Health major, School of Health Science, Mae Fah Luang University, Mueang Chiang Rai District, Chiang Rai, Thailand.
²⁶ Department of Frontier Sciences for Advanced Environment, Graduate School of Environmental Studies, Tohoku University, Sendai, Miyagi, Japan.
²⁷ Department of Civil and Environmental Engineering, Graduate School of Engineering, Tohoku University, Sendai, Miyagi, Japan.
²⁸ Translational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Pathum Wan, Bangkok, Thailand.
²⁹ Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok, Thailand.
³⁰ Center of Excellence in Kidney Metabolic Disorders, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok, Thailand.
³¹ Dialysis Policy and Practice Program (DiP3), School of Global Health, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok, Thailand.
³² Peritoneal Dialysis Excellence Center, King Chulalongkorn Memorial Hospital, Pathum Wan, Bangkok, Thailand.
³³ Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Albertus-Magnus-Platz, Cologne, Germany.
³⁴ German Centre for Infection Research, Partner site Bonn-Cologne, Albertus-Magnus-Platz, Cologne, Germany.
³⁵ Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Albertus-Magnus-Platz, Cologne, Germany.
³⁶ The National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Bunkyo-machi, Nagasaki, Japan.
³⁷ Wal-Yan Respiratory Research Centre, Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
³⁸ Centre for Cell Therapy and Regenerative Medicine, Medical School, The University of Western Australia, Nedlands, Western Australia, Australia.
³⁹ Department of Respiratory and Sleep Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.
⁴⁰ School of Population Health, Curtin University, Bentley, Bentley, 6102, Western Australia, Australia.
⁴¹ UK Centre for Ecology & Hydrology, Crowmarsh Gifford, Wallingford, UK.
⁴² School of Environmental Science, University of Auckland, Auckland CBD, Auckland, New Zealand.
⁴³ King's British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Denmark Hill Campus, The James Black Centre, 125 Coldharbour Lane, London, UK.
⁴⁴ Vascular Biology and Inflammation Section, School of Cardiovascular Medicine and Sciences, King's College London, Denmark Hill Campus, The James Black Centre, 125 Coldharbour Lane, London, UK.
⁴⁵ Department of Physiology, Anatomy & Genetics, University of Oxford, Broad St, Oxford, UK.
⁴⁶ Tokyo Foundation for Policy Research, Tokyo, Japan.
⁴⁷ Yamagata Prefectural University of Health Sciences, Aoyagi, Yamagata, Japan.
⁴⁸ Mae Fah Luang University Hospital, Mueang Chiang Rai,Chiang Rai, Thailand.
⁴⁹ School of Integrative Medicine, Mae Fah Luang University, Mueang Chiang Rai,Chiang Rai, Thailand.

PMID: 37462504
DOI: 10.1093/jtm/taad096

Abstract

High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.

Keywords: Southeast Asia; Tracing; WBE; mpox; surveillances; transmission; wastewaters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asia, Southeastern / epidemiology
Humans
Mpox (monkeypox)*
Wastewater*
Wastewater-Based Epidemiological Monitoring

Substances

Wastewater

Abstract

Publication types

MeSH terms

Substances

Grants and funding