Recent Progress in Asymmetric Domino Intramolecular Cyclization/Cascade Reactions of Substituted Olefins

Liang Zou; Yuan Gao; Qiaoman Zhang; Xiang-Yang Ye; Tian Xie; Li-Wei Wang; Yang Ye

doi:10.1002/asia.202300617

Recent Progress in Asymmetric Domino Intramolecular Cyclization/Cascade Reactions of Substituted Olefins

Chem Asian J. 2023 Sep 15;18(18):e202300617. doi: 10.1002/asia.202300617. Epub 2023 Jul 31.

Authors

Liang Zou¹, Yuan Gao², Qiaoman Zhang¹, Xiang-Yang Ye¹, Tian Xie¹, Li-Wei Wang¹, Yang Ye¹

Affiliations

¹ School of Pharmacy, Hangzhou Normal University, Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou, Zhejiang 311121, P. R. China.
² Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 200000, P. R. China.

PMID: 37462417
DOI: 10.1002/asia.202300617

Abstract

The domino cyclization/coupling strategy is one of the most effective methods to produce cyclized and multi-functionalized compounds from olefins, which has attracted huge attention from chemists and biochemists especially for its considerable potential of enantiocontrol. Nowadays, more and more studies are developed to achieve difunctionalization of substituted olefins through an asymmetric domino intramolecular cyclization/cascade reaction, which is still an elegant choice to accomplish several synthetic ideas such as complex natural products and drugs. This review surveys the recent advances in this field through reaction type classification. It might serve as useful knowledge desktop for the community and accelerate their research.

Keywords: Cascade reaction; Cross-coupling; Domino cyclization; Enantioselective; Olefins.

Publication types

Review

Abstract

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