This comprehensive review was carried out to integrate all the data published in the electronic databases (Scopus, etc.) over the past two decades about the distribution, phytochemistry, ethnopharmacology, and pharmacology of Astragalus L. Although Astragalus is one of the largest genera of flowering plants in Iran, limited phytochemical screening of this genus has been reported. Cycloartane triterpene glycosides, labdane diterpenoids, flavonoids, and polysaccharides are the major identified compounds. Pharmacological studies revealed significant properties such as anti-inflammatory, anticancer, antidiabetic, etc. Moreover, ethnopharmacological studies of Astragalus sp. showed that this genus is used for gastrointestinal, fractures, joint pains, and skin problems in different localities of Iran. Tragacanth gum, as the main product of some Astragalus sp. with economic value, shows proper biological activities and uses as an emulsifier in food industries. This review might be helpful for researchers to find new chemical entities responsible for its claimed traditional uses and food supplements.
Keywords: Astragalus; Iran; gum tragacanth; pharmacological activities; phytochemistry.