Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics

Madhukar H Trivedi; Abu Minhajuddin; Holli Slater; Regina Baronia; Joseph C Blader; Jamon Blood; Ryan Brown; Cynthia Claassen; Melissa DeFilippis; David Farmer; Cynthia Garza; Jennifer L Hughes; Beth D Kennard; Israel Liberzon; Sarah Martin; Taryn L Mayes; Jair C Soares; Cesar A Soutullo; Eric A Storch; Sarah M Wakefield

doi:10.1016/j.jad.2023.07.035

Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics

J Affect Disord. 2023 Nov 1:340:88-99. doi: 10.1016/j.jad.2023.07.035. Epub 2023 Jul 17.

Authors

Madhukar H Trivedi¹, Abu Minhajuddin², Holli Slater³, Regina Baronia⁴, Joseph C Blader⁵, Jamon Blood⁶, Ryan Brown⁷, Cynthia Claassen⁸, Melissa DeFilippis⁹, David Farmer¹⁰, Cynthia Garza¹¹, Jennifer L Hughes¹², Beth D Kennard¹³, Israel Liberzon¹⁴, Sarah Martin¹⁵, Taryn L Mayes³, Jair C Soares¹⁶, Cesar A Soutullo¹⁶, Eric A Storch¹⁷, Sarah M Wakefield⁴

Affiliations

¹ Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: Madhukar.Trivedi@utsouthwestern.edu.
² Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
³ Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁴ Department of Psychiatry, Texas Tech University Health Science Center, Lubbock, TX, USA.
⁵ University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
⁶ University of Texas Health Science Center, Tyler, TX, USA.
⁷ University of Texas at Austin Dell Medical School, Austin, TX, USA.
⁸ JPS Health Network, Fort Worth, TX, USA.
⁹ University of Texas Medical Branch, Galveston, TX, USA.
¹⁰ University of North Texas Health Science Center, Fort Worth, TX, USA.
¹¹ Department of Psychiatry, University of Texas Rio Grande Valley, School of Medicine, Edinburg, TX, USA.
¹² Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
¹³ Department of Psychiatry, University of Texas Southwestern Medical Center in Dallas, TX, USA.
¹⁴ Texas A&M University Health Science Center, Bryan, TX, USA.
¹⁵ Texas Tech University Health Science Center, El Paso, TX, USA.
¹⁶ University of Texas Health Science Center, Houston, TX, USA.
¹⁷ Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.

PMID: 37459975
DOI: 10.1016/j.jad.2023.07.035

Abstract

Background: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.

Methods: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.

Results: Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).

Limitations: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.

Conclusions: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.

Keywords: Collaborative research network; Depression; Suicide; Treatment; Youth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Delivery of Health Care*
Depression* / therapy
Female
Humans
Male
Prospective Studies
Registries
Texas / epidemiology