A quantitative description of the compatibility of technetium-selective chromatographic technetium-99m separation with low specific activity molybdenum-99

Jaewoong Jang; Shun Sekimoto; Tsutomu Ohtsuki; Katsuyoshi Tatenuma; Akira Tsuguchi; Mitsuru Uesaka

doi:10.1016/j.chroma.2023.464192

A quantitative description of the compatibility of technetium-selective chromatographic technetium-99m separation with low specific activity molybdenum-99

J Chromatogr A. 2023 Aug 30:1705:464192. doi: 10.1016/j.chroma.2023.464192. Epub 2023 Jul 3.

Authors

Jaewoong Jang¹, Shun Sekimoto², Tsutomu Ohtsuki², Katsuyoshi Tatenuma³, Akira Tsuguchi³, Mitsuru Uesaka⁴

Affiliations

¹ Department of Bioengineering, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan; Isotope Science Center, University of Tokyo, 2-11-16 Yayoi, Bunkyo, Tokyo 113-0032, Japan. Electronic address: jang@ric.u-tokyo.ac.jp.
² Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashironishi, Kumatori, Sennan, Osaka 590-0494 Japan.
³ Kaken Inc., 1044 Hori, Mito, Ibaraki 310-0903, Japan.
⁴ Department of Bioengineering, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan; Nuclear Professional School, School of Engineering, University of Tokyo, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki 319-1188, Japan.

PMID: 37459808
DOI: 10.1016/j.chroma.2023.464192

Abstract

Technetium-99m generators employing a technetium-selective stationary phase are a chromatographic instrument developed for use with ⁹⁹Mo having low specific activity (LSA); particularly, ⁹⁹Mo produced by electron accelerators. This paper presents a mathematical description of technetium-selective chromatographic (TSC) ^99mTc separation and analyzes its compatibility with LSA ⁹⁹Mo. We developed a theoretical formula for TSC ^99mTc separation by discretizing its pertechnetate selectivity, and validated it using an electron linear accelerator and activated carbon-based TSC (AC-TSC) ^99mTc generators. We confirmed that the activity concentration of ^99mTc obtained from a TSC ^99mTc generator can be calculated directly from its input ⁹⁹Mo activity regardless of the ⁹⁹Mo specific activity. The formula corroborates that TSC ^99mTc separation is compatible with LSA ⁹⁹Mo, and has a practical application in estimating the number of TSC ^99mTc generators required for ^99mTc demand of interest.

Keywords: Activity concentration; Chromatographic separation; Molybdenum-99; Specific activity; Technetium-99m.

MeSH terms

Electrons
Molybdenum / chemistry
Radioisotopes*
Technetium* / chemistry

Substances

Molybdenum-99
Technetium
Radioisotopes
Molybdenum