Pan-cancer analysis shows that IBSP is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including osteosarcoma

Boyu Pan; Xiaoyun Cheng; Wei Tan; Renfeng Liu; Xin Wu; Jinpeng He; Qizhi Fan; Yan Zhang; Jun Cheng; Youwen Deng

doi:10.3389/fimmu.2023.1188256

Pan-cancer analysis shows that IBSP is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including osteosarcoma

Front Immunol. 2023 Jun 29:14:1188256. doi: 10.3389/fimmu.2023.1188256. eCollection 2023.

Authors

Boyu Pan¹, Xiaoyun Cheng^{2

3}, Wei Tan¹, Renfeng Liu¹, Xin Wu¹, Jinpeng He¹, Qizhi Fan¹, Yan Zhang³, Jun Cheng^{1

4}, Youwen Deng¹

Affiliations

¹ Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
³ Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Abstract

Background: IBSP is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that plays a vital role in bone formation, renewal and repair. Emerging evidence revealed that IBSP participated in the tumorigenesis and progression in some cancers. However, its significance in tumour prognosis and immunotherapy is still unknown.

Methods: In the current study, we studied the role of IBSP in tumorigenesis, tumor diagnosis, genomic heterogeneity, methylation modifications, immune infiltration, and therapy response in pan-cancer. In addition, we constructed a risk score model to assessed the prognostic classification efficiency of IBSP using the co-expression genes of IBSP in osteosarcoma (OS), and analyzed the expression and role of IBSP in OS through a series of assays in vitro.

Results: IBSP was upregulated in various cancers compared to the paired normal tissues, and it was strongly correlated with the prognosis, pathological stage, diagnostic accuracy, genomic heterogeneity, methylation modification, immune infiltration, immune and checkpoint. Moreover, the predictive model we established in combination with the clinical characteristics of OS patients showed high survival predictive power in these individuals. The assays in vitro showed that IBSP promoted the proliferation, migration and invasion of OS cells, which further confirmed IBSP's role in cancers.

Conclusions: Our research revealed the multifunctionality of IBSP in the tumorigenesis, progression and therapy in various cancers, which demonstrated that IBSP may serve as a potential prognostic biomarker and a novel immunotherapy target in pan-cancer.

Keywords: IBSP; immunotherapy; osteosarcoma; pan-cancer; prognosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Bone Neoplasms* / genetics
Bone Neoplasms* / therapy
Carcinogenesis
Cell Transformation, Neoplastic
Humans
Immunotherapy
Osteosarcoma* / genetics
Osteosarcoma* / therapy
Prognosis

Substances

Biomarkers

Grants and funding

This work was supported by the Science and Technology Program of Hunan Province (2021RC4057); Postgraduate Scientific Research Innovation Project of Hunan Province (150110027).