Blended extract of oat, sorghum, adzuki bean, finger millet, and proso millet improved hyperglycemia and insulin resistance in the streptozotocin-nicotinamide-induced diabetic rats

Yun Sun Yang; Eun Woo Jeong; Youjin Baek; Gwang-Woong Go; Hyeon Gyu Lee

doi:10.1007/s10068-023-01340-y

Blended extract of oat, sorghum, adzuki bean, finger millet, and proso millet improved hyperglycemia and insulin resistance in the streptozotocin-nicotinamide-induced diabetic rats

Food Sci Biotechnol. 2023 Jun 15;32(10):1415-1421. doi: 10.1007/s10068-023-01340-y. eCollection 2023 Sep.

Authors

Yun Sun Yang¹, Eun Woo Jeong¹, Youjin Baek¹, Gwang-Woong Go¹, Hyeon Gyu Lee¹

Affiliation

¹ Department of Food and Nutrition, Hanyang University, Seoul, 04763 Korea.

PMID: 37457409
PMCID: PMC10349016 (available on 2024-06-15)
DOI: 10.1007/s10068-023-01340-y

Abstract

Grains contain bioactive components that potentially have protective effects on chronic diseases such as diabetes. The anti-diabetic effects of blended grain ethanol extract (BGE) were evaluated in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats. BGE was prepared by mixing oat, sorghum, adzuki bean, finger millet, and proso millet (30:30:15:15:10). The rats were assigned into four groups, normal control, diabetic model control (DM), STZ-NA rats administered 200 mg/kg body weight (bw) of metformin, and STZ-NA rats administered 500 mg/kg bw of BGE (BGE). After 6 weeks of administration, the homeostatic model assessment of insulin resistance (12%) in BGE decreased compared to DM. Strikingly, the fasting blood glucose (23%) and oral glucose tolerance test (15%) were improved in BGE compared to DM. BGE also increased insulin immunoreactivities in pancreatic β-cells. In sum, BGE exhibits anti-hyperglycemic effects by improving fasting glucose levels and insulin secretion from pancreatic β-cells in the STZ-NA-induced diabetic rats.

Keywords: Adzuki bean; Finger millet; Oat; Proso millet; Sorghum.

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