Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries

Zeshu Zhu; Ping Zhu; Xiongwei Fan; Xiaoyang Mo; Xiushan Wu

doi:10.3389/fcell.2023.1093113

Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries

Front Cell Dev Biol. 2023 Jun 30:11:1093113. doi: 10.3389/fcell.2023.1093113. eCollection 2023.

Authors

Zeshu Zhu¹, Ping Zhu^{2

3}, Xiongwei Fan¹, Xiaoyang Mo¹, Xiushan Wu^{1

3}

Affiliations

¹ The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
² Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
³ Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou, Guangdong, China.

Abstract

Mesenchymal stem cells (MSCs) are one of the most potent therapeutic strategies for repairing cardiac injury. It has been shown in the latest studies that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secreted by MSCs may dominate the repair of heart injury and promote the restoration of cardiac cells, vascular proliferation, immune regulation, etc. Based on the current research, the progress of the acting mechanism, application prospects and challenges of exosomes, including non-coding RNA, in repairing cardiac injuries are summarised in this article.

Keywords: exosomes; heart injury; mesenchymal stem cells; miRNA; non-coding RNA.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (Nos. 81970324, 81670290, and 81974019), National Key Research and Development Program of China (2018YFA0108700), Guangdong Provincial Special Support Program for Prominent Talents (2021JC06Y656), Science and Technology Planning Project of Guangdong Province (2020B1111170011, 2022B1212010010), Stability support for scientific research institutions affiliated to Guangdong Province-GDCI 2021, the Marine Economy Development Project of Department of Natural Resources of Guangdong Province (GDNRC[2022]039), Guangzhou Science Research Plan (202201000006). The Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital (KJ012019119).