IgA nephropathy associated with Crohn's disease

Abstract

The relationship between IgA nephropathy (IgAN) and Crohn's disease was reported. IgAN is the most common primary glomerulonephritis and one of the leading causes of chronic kidney disease and end-stage renal failure, and up to 50% of cases progressed to end-stage renal disease within 25 years after IgAN diagnosis. However, specific and effective therapeutic strategies are still lacking. In this review, we discuss the possibility of the mechanism involved in IgAN associated with Crohn's disease based on the findings of basic and clinical studies. Although the etiology of IgAN associated with Crohn's disease is not permanent and various factors are thought to be involved, the stabilization of the disease condition of Crohn's disease is believed to help treat IgAN.

Keywords: Crohn’s disease; Gut-associated lymphoid tissue; IgA nephropathy; Immunological abnormalities; Mucosal-associated lymphoid tissue; Nasopharynx-associated lymphoid tissue.