Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms

Xudong Yu; Ruijia Liu; Lianying Song; Wenfeng Gao; Xuyun Wang; Yaosheng Zhang

doi:10.3389/fonc.2023.1165732

Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms

Front Oncol. 2023 Jun 30:13:1165732. doi: 10.3389/fonc.2023.1165732. eCollection 2023.

Authors

Xudong Yu^{1

2}, Ruijia Liu¹, Lianying Song¹, Wenfeng Gao¹, Xuyun Wang³, Yaosheng Zhang^{1

2}

Affiliations

¹ Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
² Beijing Tumor Minimally Invasive Medical Center of Integrated Traditional Chinese and Western Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine and Beijing Municipal Health Commission, Beijing, China.
³ Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

Abstract

Since the theory of modern anatomical partitioning of the prostate was proposed, the differences in the incidence and pathological parameters of prostate cancer between the peripheral zone and transition zone have been gradually revealed. It suggests that there are differences in the pathogenic pathways and molecular biology of prostate cancer between different regions of origin. Over the past decade, advances in sequencing technologies have revealed more about molecules, genomes, and cell types specific to the peripheral and transitional zones. In recent years, the innovation of spatial imaging and multiple-parameter magnetic resonance imaging has provided new technical support for the zonal study of prostate cancer. In this work, we reviewed all the research results and the latest research progress in the study of prostate cancer in the past two decades. We summarized and proposed several vital issues and focused directions for understanding the differences between peripheral and transitional zones in prostate cancer.

Keywords: MRI; clinical characters; heterogeneity; prostate cancer; zones.

Publication types

Review

Grants and funding

This research was supported in part by the Fundamental Research Funds for the Central Universities, Dongzhimen Hospital, Beijing University of Chinese Medicine; the Beijing Traditional Chinese Medicine “Torch Inheritance 3 + 3 Project”-the Wang Pei Famous Doctor Inheritance Workstation-Dongzhimen Hospital Branch; the Wu Jie-ping Medical Foundation Special Fund for Young people with TCM dominant diseases; and the Science and Technology Development Fund of Beijing Traditional Chinese Medicine Hospital affiliated to Capital Medical University, No. LYYB202214.