Wells Syndrome with Generalized Oedema

Magdalini Manti; Efthymia Pappa; Vasiliki Arkouli; Leonidas Marinos; Constantinos Christopoulos

doi:10.12890/2023_003954

Wells Syndrome with Generalized Oedema

Eur J Case Rep Intern Med. 2023 Jun 19;10(7):003954. doi: 10.12890/2023_003954. eCollection 2023.

Authors

Magdalini Manti¹, Efthymia Pappa¹, Vasiliki Arkouli¹, Leonidas Marinos², Constantinos Christopoulos¹

Affiliations

¹ First Internal Medicine Department, "Sismanoglio" General Hospital, Athens, Greece.
² Department of Hematopathology "Evangelismos" General Hospital, Athens, Greece.

Abstract

Wells syndrome or eosinophilic cellulitis is a rare and relapsing skin disease which lacks systemic involvement. A skin biopsy is needed to establish a diagnosis. Several precipitating factors have been proposed but no proven causative link has been found. On the other hand, Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA), an auto-immune disease, is associated with multiorgan, including cutaneous manifestations. We report a case with overlapping features of Wells and Churg-Strauss syndrome, suggesting that these syndromes could be part of the same nosological entity.

Learning points: Biopsies are essential to establish a diagnosis in unusual cases of cellulitis.COVID-19 vaccination is a putative trigger for Wells syndrome.There is significant overlap between Wells and Churg-Strauss syndromes.

Keywords: Churg-Strauss syndrome; Wells syndrome; cellulitis; eosinophilia; vasculitis.