Psychiatric comorbidities in adults with sickle cell disease: A narrative review

Br J Haematol. 2023 Dec;203(5):747-759. doi: 10.1111/bjh.18981. Epub 2023 Jul 16.

Abstract

Although descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We provide a narrative review of what is known about common and debilitating psychiatric conditions such as depression, anxiety, and cognitive impairment, specifically for adults with SCD. We discuss the limitations of the current evidence, make provisional recommendations, and identify opportunities for research and improved care.

Keywords: consultation-liaison; depression; equity; psychiatry; sickle cell disease.

Publication types

  • Review

MeSH terms

  • Adult
  • Anemia, Sickle Cell* / complications
  • Anemia, Sickle Cell* / epidemiology
  • Anemia, Sickle Cell* / psychology
  • Anxiety* / epidemiology
  • Cognitive Dysfunction* / epidemiology
  • Comorbidity
  • Depression* / epidemiology
  • Humans
  • Quality of Life