Recent development of chiral ionic liquids for enantioseparation in liquid chromatography and capillary electrophoresis: A review

Huifeng Liu; Jia Chen; Mingli Chen; Jianhua Wang; Hongdeng Qiu

doi:10.1016/j.aca.2023.341496

Recent development of chiral ionic liquids for enantioseparation in liquid chromatography and capillary electrophoresis: A review

Anal Chim Acta. 2023 Sep 15:1274:341496. doi: 10.1016/j.aca.2023.341496. Epub 2023 Jun 15.

Authors

Huifeng Liu¹, Jia Chen², Mingli Chen³, Jianhua Wang⁴, Hongdeng Qiu⁵

Affiliations

¹ Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
² CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. Electronic address: jiachen@licp.cas.cn.
³ Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China.
⁴ Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China. Electronic address: jianhuajrz@mail.neu.edu.cn.
⁵ CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000, China. Electronic address: hdqiu@licp.cas.cn.

PMID: 37455089
DOI: 10.1016/j.aca.2023.341496

Abstract

Ionic liquids (ILs), which are salts in a molten state below 100 °C, have become a hot topic of research in various fields because of their negligible vapour pressure, high thermal stability, and tunable viscosity. Chiral ionic liquids (CILs) can be applied in chromatography and capillary electrophoresis fields to improve the performance of enantiomeric separation, such as chiral stationary phases (CSPs) and mobile phase additives in high-performance liquid chromatography (HPLC); CSPs in gas chromatography (GC); and background electrolyte additives (BGE), chiral ligands and chiral selectors (CSs) in capillary electrophoresis (CE). This review focuses on the applications of CILs in HPLC and CE for the separation of enantiomers in the past five years. The mechanism for separating enantiomers was explained, and the prospect of the application of CILs in chiral liquid chromatography (LC) and CE analysis was also discussed.

Keywords: Capillary electrophoresis; Chiral ionic liquids; Chiral separation; Chiral stationary phase; Liquid chromatography.

Publication types

Review