Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases

Yani Lin; Liyuan Ran; Ximing Du; Hongyuan Yang; Yingjie Wu

doi:10.1016/j.bbalip.2023.159365

Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases

Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Sep;1868(9):159365. doi: 10.1016/j.bbalip.2023.159365. Epub 2023 Jul 16.

Authors

Yani Lin¹, Liyuan Ran², Ximing Du³, Hongyuan Yang⁴, Yingjie Wu⁵

Affiliations

¹ Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China.
² Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China; Institute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning 116044, China.
³ School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia.
⁴ School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: H.Rob.Yang@unsw.edu.au.
⁵ Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China; Institute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Molecular Pathobiology, New York University College of Dentistry, New York 10010, USA. Electronic address: yjwu@sdfmu.edu.cn.

PMID: 37455011
DOI: 10.1016/j.bbalip.2023.159365

Abstract

Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases.

Keywords: Cholesterol; Disease; OSBP; PI4P; Virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Transport*
Humans
Lipid Metabolism* / physiology
Lipids
Oxysterols* / metabolism

Substances

Lipids
Oxysterols