Primary ciliary dyskinesia (PCD) is an autosomal recessive genetic disease. Gene mutation leads to ciliary structural abnormalities or functional defects, resulting in respiratory diseases. Male patients with PCD are prone to infertility, which pathogenically may be attributed to gene mutation-induced dysfunction of respiratory cilia and sperm flagella. This reviews focuses on the research progress in microtubule structure, gene mutation and outcomes of assisted reproduction relating to PCD complicated by male infertility.
Keywords: assisted reproduction; gene; male infertility; primary ciliary dyskinesia.