Efficacy of UV and UV-LEDs Irradiation Models for Microbial Inactivation Applicable to Automated Sterile Drug Compounding

Raffaella Campana; Sofia Moroni; Demis Paolucci; Matteo Federici; Luca Casettari; Emanuela Frangipani

doi:10.1016/j.xphs.2023.07.008

Efficacy of UV and UV-LEDs Irradiation Models for Microbial Inactivation Applicable to Automated Sterile Drug Compounding

J Pharm Sci. 2023 Sep;112(9):2389-2392. doi: 10.1016/j.xphs.2023.07.008. Epub 2023 Jul 14.

Authors

Raffaella Campana¹, Sofia Moroni², Demis Paolucci³, Matteo Federici³, Luca Casettari², Emanuela Frangipani²

Affiliations

¹ Department of Biomolecular Sciences, University of Urbino, Via S. Chiara 27, 61029, Urbino PU, Italy. Electronic address: raffaella.campana@uniurb.it.
² Department of Biomolecular Sciences, University of Urbino, Via S. Chiara 27, 61029, Urbino PU, Italy.
³ Loccioni, Angeli di Rosora AN, Italy.

PMID: 37453527
DOI: 10.1016/j.xphs.2023.07.008

Abstract

LEDs development has attracted attention over conventional mercury lamps for the tiny size, high efficiency, long lifetime, low operating temperature. The antimicrobial effectiveness of traditional UV-lamps radiation (wavelength of 254 nm) compared to UV-C LEDs (LED1 wavelength range 275-286 nm and LED2 range 260-270 nm) was carried out, for possible applications to automated sterile drug compounding. The UV lamp and the tested UV-LED devices remarkably reduced microbial load, following a time-dose response, but the best performance was evidenced by LED1, which guaranteed the complete inactivation of high concentrations of bacteria, yeasts, and spores at doses between 200 and 2000 J/m².

Keywords: Aseptic compounding; Microbial inactivation; Sanitization; UV-LED; Ultraviolet radiation.

MeSH terms

Bacteria
Disinfection*
Drug Compounding
Microbial Viability
Ultraviolet Rays*