The trigger for pancreatic disease: NLRP3 inflammasome

Tianming Liu; Qiang Wang; Zhiwei Du; Lu Yin; Jiachen Li; Xianzhi Meng; Dongbo Xue

doi:10.1038/s41420-023-01550-7

The trigger for pancreatic disease: NLRP3 inflammasome

Cell Death Discov. 2023 Jul 14;9(1):246. doi: 10.1038/s41420-023-01550-7.

Authors

Tianming Liu^#^{1

2}, Qiang Wang^#^{1

2}, Zhiwei Du^{1

2}, Lu Yin^{1

2}, Jiachen Li^{1

2}, Xianzhi Meng^{3

4}, Dongbo Xue^{5

6}

Affiliations

¹ Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
² Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
³ Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. mengxianzhi@hrbmu.edu.cn.
⁴ Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. mengxianzhi@hrbmu.edu.cn.
⁵ Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. xuedongbo@hrbmu.edu.cn.
⁶ Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. xuedongbo@hrbmu.edu.cn.

^# Contributed equally.

Abstract

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases. Through this article, we provide a relatively comprehensive summary to the researchers in this field, and provide some targeted therapy routes.

Publication types

Review

Abstract

Publication types

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