The mitochondria in schizophrenia with 22q11.2 deletion syndrome: From pathogenesis to therapeutic promise of targeted natural drugs

Zongxiang Xiong; Heting Wang; Yutian Qu; Sihan Peng; Yuchi He; Qingyan Yang; Xinyue Xu; De Lv; Ya Liu; Chunguang Xie; Xiyu Zhang

doi:10.1016/j.pnpbp.2023.110831

The mitochondria in schizophrenia with 22q11.2 deletion syndrome: From pathogenesis to therapeutic promise of targeted natural drugs

Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20:127:110831. doi: 10.1016/j.pnpbp.2023.110831. Epub 2023 Jul 13.

Authors

Zongxiang Xiong¹, Heting Wang², Yutian Qu³, Sihan Peng⁴, Yuchi He³, Qingyan Yang³, Xinyue Xu³, De Lv⁴, Ya Liu⁴, Chunguang Xie⁴, Xiyu Zhang⁵

Affiliations

¹ Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² Department of Traditional Chinese Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
⁴ Hospital of Chengdu University of Traditional Chinese Medicine, TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, China.
⁵ Hospital of Chengdu University of Traditional Chinese Medicine, TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, China. Electronic address: zhangxiyutcm@163.com.

PMID: 37451595
DOI: 10.1016/j.pnpbp.2023.110831

Abstract

Schizophrenia is a complex multi-factor neurological disorder that caused an array of severe indelible consequences to the individuals and society. Additionally, anti-schizophrenic drugs are unsuitable for treating negative symptoms and have more significant side effects and drug resistance. For better treatment and prevention, we consider exploring the pathogenesis of schizophrenia from other perspectives. A growing body of evidence of 22q11.2 deletion syndrome (22q11DS) suggested that the occurrence and progression of schizophrenia are related to mitochondrial dysfunction. So combing through the literature of 22q11DS published from 2000 to 2023, this paper reviews the mechanism of schizophrenia based on mitochondrial dysfunction, and it focuses on the natural drugs targeting mitochondria to enhance mitochondrial function, which are potential to improve the current treatment of schizophrenia.

Keywords: 22q11DS; Mitochondria; Schizophrenia; Targeted natural drugs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

DiGeorge Syndrome* / pathology
Humans
Mitochondria / pathology
Schizophrenia*